Course27617
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Course 27617: Protein Structure and Computational Biology
The three-dimensional structure and flexibility of proteins determine their function in biological processes. Knowledge about protein structure is used in structure-based drug design and optimization of biocatalysts. In cases where an experimental structure is not available for the protein of interest, homology modelling may be used to generate structural models for hypothesis-driven research. The goal of structural genomics projects is to map protein fold space and thus to allow generation of useful homology models for all proteins.
In this course, students will analyze protein structures using the program PyMOL. Key examples will be taken from influenza virus, where the molecular mechanisms underlying the different phases of the virus life cycle will be investigated. This will give the students a deeper understanding of protein structure analysis and knowledge about the newest techniques in homology modeling, protein engineering and directed evolution.
Course contents
- Elements of protein structure
- Structural databases
- Structural genomics
- Fold recognition and homology modeling
- Structure validation
- Structure analysis
- Structure visualisation (with PyMOL)
Pratical information
What: The course will be taught in English and consists of lectures and computer exercises. The students will be introduced to protein structure in general as well as a range of computational tools, methods and web-based services for the analysis and modelling of protein structures. The course is aimed at master students, but may also be relevant for bachelor students on their 5th or 6th semester as well as PhD-students. All students from DTU and other universities are welcome.
Please see the DTU Study Handbook for details regarding course #27617.
How: If you want to participate in the course, please sign up through the Studies Division - "studiekontoret" - at DTU. If you are not enrolled at the Technical University of Denmark, you have to sign up as a guest student (more information here: General Information for guest students from other Danish Universities)
Where: Lectures and exercises will take place at DTU, building 208 in room 062 (in the basement below CBS). Directions and a campus map is available here. Occasional changes to the location will be announced on CampusNet as well as in the programme.
Help: For more information, please contact: Associate Professor Thomas Holberg Blicher (blicher@cbs.dtu.dk) or course coordinator Dorthe Kjærsgaard (dorthek@cbs.dtu.dk).
PyMOL
In this course we will be using PyMOL for visualizing protein structures. More information and downloads can be found here.
Course material
Presentations and exercise instructions will generally be made available on the programme page (see below). Copyrighted material will only be made available on CampusNet.
Course programme
Current:
Previous:
CampusNet
Evaluations and Feedback
Remember that you can give running evaluations and feedback at the Bio-Evaluering debate forum.
Curriculum
See course programme.
Related Courses
- Course 26325 - Protein Crystallography
- Course 10355 - Molecular Biophysics: Protein, Structure and Dynamics
- Course 26422 - Biomolecular Chemistry
- Course 26426 - Introduction to Medicinal Chemistry
- Course 27508 - Enzyme Discovery og Engineering
Links
- Poster guidelines (external link)
Amino Acids
- Amino acid properties (under construction).
- Amino acid quiz
- Another amino acid quiz
- Yet another amino acid quiz...
- Last amino acid quiz...
Fun Stuff
Peptide words
